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Dapsone 7.5% Gel Versus Trichloroacetic Acid Peels
Dalia A Atallah1, Sahar R Bestawy2, Sara A Abouelmajd3
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Summary
Dapsone 7.5% gel and trichloroacetic acid (TCA) 20% peel showed similar effectiveness for mild to moderate acne vulgaris. Dapsone gel was more effective for inflammatory acne lesions.
Area of Science:
- Dermatology
- Clinical Research
- Dermatological Treatments
Background:
- Acne vulgaris is a common skin condition impacting self-esteem.
- Dapsone is an antibacterial and anti-inflammatory drug.
- Adult acne presents unique challenges.
Purpose of the Study:
- Compare dapsone 7.5% gel and trichloroacetic acid (TCA) 20% peel for acne vulgaris.
- Evaluate treatment efficacy, tolerability, and safety.
- Assess outcomes in adult patients.
Main Methods:
- Split-face, quasi-experimental clinical study.
- Thirty patients with acne vulgaris participated.
- Dapsone gel applied nightly; TCA peels applied bi-weekly for 3 months.
Main Results:
- Both treatments significantly reduced acne lesions and Global Acne Grading Score (GAGS).
- Minimal difference observed in overall efficacy between dapsone gel and TCA peel.
- Dapsone gel demonstrated greater efficacy for inflammatory acne lesions.
Conclusions:
- Dapsone 7.5% gel and TCA 20% peel offer comparable clinical effectiveness for mild to moderate acne vulgaris.
- Dapsone gel shows a specific advantage in treating inflammatory acne.
- Both treatments are viable options for acne management.
