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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Treating glioblastoma with dextrin-based polymers.

Chiara Bastiancich1, Chiara Molinar1,2, A Tchoghandjian1,3

  • 1Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.

Expert Opinion on Drug Delivery
|October 3, 2025
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Summary
This summary is machine-generated.

Cyclodextrin-based polymers show promise for glioblastoma treatment. These biodegradable drug delivery systems enhance anticancer agent permeation across the blood-brain barrier, offering a potential new therapeutic strategy.

Keywords:
Blood-Brain BarrierBrain tumorsCentral Nervous SystemCyclodextrinDextrinDrug deliveryGlioblastoma

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Area of Science:

  • Polymer Science
  • Nanotechnology
  • Oncology

Background:

  • Glioblastoma is an aggressive brain tumor with limited treatment options.
  • Dextrins and cyclodextrins are starch derivatives with potential for drug delivery.
  • Cyclodextrins can interact with the blood-brain barrier to improve drug permeation.

Purpose of the Study:

  • To review dextrin- and cyclodextrin-based polymeric systems for glioblastoma drug delivery.
  • To highlight the potential of these systems in overcoming therapeutic challenges.
  • To summarize preclinical studies and discuss future directions.

Main Methods:

  • Review of preclinical studies on cyclodextrin-based drug delivery systems for glioblastoma.
  • Analysis of cyclodextrin interactions with the blood-brain barrier.
  • Evaluation of various anticancer agents delivered via cyclodextrin formulations.

Main Results:

  • Cyclodextrin-based systems demonstrate potential for delivering diverse anticancer agents.
  • These systems show promise in enhancing drug permeation across the blood-brain barrier.
  • Preclinical studies indicate favorable features for glioblastoma therapy.

Conclusions:

  • Cyclodextrin-based polymers offer innovative platforms for glioblastoma treatment.
  • Despite challenges, these systems hold significant potential for clinical application.
  • Further research is needed to translate these findings into effective therapies.