JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Assessing the use of modified 5-item frailty index as a prognostic marker of long-term survival and perioperative outcomes after radical cystectomy for bladder cancer

  • 0University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Urology, Zuhuratbaba Mah, Dr. Tevfik Sağlam Cd No:11, 34147, Bakırköy, Istanbul, Turkey. ubeydsungur@gmail.com.
Irish Journal of Medical Science +

|

October 3, 2025

|

October 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The preoperative Modified 5-item Frailty Score (mFI-5) is a significant predictor of long-term survival in bladder cancer patients undergoing radical cystectomy. A higher mFI-5 score indicates worse overall and cancer-specific survival, highlighting its prognostic value.

Area Of Science

  • Urology
  • Oncology
  • Geriatrics

Background

  • Radical cystectomy is a standard treatment for muscle-invasive bladder cancer.
  • Assessing preoperative patient risk is crucial for surgical outcomes.
  • The Modified 5-item Frailty Score (mFI-5) is a validated frailty assessment tool.

Purpose Of The Study

  • To evaluate the association between preoperative Modified 5-item Frailty Score (mFI-5) and survival outcomes after radical cystectomy.
  • To determine if mFI-5 predicts 30-day postoperative complications in this patient cohort.

Main Methods

  • Retrospective analysis of 288 patients undergoing radical cystectomy (2012-2023).
  • Patients stratified into low-risk (mFI-5 ≤ 1) and high-risk (mFI-5 ≥ 2) groups.
  • Comparison of overall survival (OS), cancer-specific survival (CSS), and postoperative complications using Cox regression analysis.

Main Results

  • High mFI-5 score was associated with significantly worse OS and CSS (p=0.002, p=0.007).
  • Higher 30-day mortality was observed in the high mFI-5 group (p=0.002), but overall complication rates did not differ significantly (p=0.120).
  • mFI-5 independently predicted OS and CSS in multivariate analysis (p=0.001, p=0.003).

Conclusions

  • The preoperative mFI-5 score is a valuable prognostic tool for bladder cancer patients undergoing radical cystectomy.
  • mFI-5 serves as an independent predictor of long-term survival.
  • Preoperative frailty assessment can aid in risk stratification and patient counseling.

Keywords: