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Updated: Jan 16, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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An Axle-Cycle Induction Strategy for the Synthesis of Chiral [2]Rotaxanes

Ranran Wang1, Conghao Shi1, Wang Xie1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.

Journal of the American Chemical Society
|October 3, 2025
PubMed
Summary

Researchers developed a new method for creating chiral rotaxanes using dynamic racemic pillar[5]arene (DMP5A) and amino acid derivatives. This breakthrough enables stereocontrolled synthesis of complex mechanically interlocked molecules.

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