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Updated: Jan 16, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Treatment of Two Combined Therapeutic Indications With One Biomaterial
Diandra S Luz1, Irina F Dragan2
1Harvard School of Dental Medicine, Boston, Massachusetts.
Abstract:
This case report describes the use of a single resorbable biomaterial composite comprised of bovine collagen and bioactive calcium apatite in a combined complex defect highlighting oral tissue regeneration. Following standard-of-care procedures, a 68-year-old patient was treated in a private practice setting with the same biomaterial for two different therapeutic indications: alveolar ridge preservation in the edentulous site of tooth No. 12 and guided tissue regeneration on the mesial surface of tooth No. 13. No other biomaterials were used in the management of the combined complex defect. Healing was uneventful, and the patient was satisfied with the final treatment. The edentulous space No. 12 was treated further with a screw-retained implant-supported restoration. At the 16-month follow-up, clinical evaluation revealed preserved ridge volume and stable keratinized soft tissue. Radiographic analysis confirmed stable bone levels for implant No. 12 and positive radiographic changes of oral regeneration on the mesial of tooth No. 13, including the re-establishment of the periodontal ligament. Within the limitations of this case report, the biomaterial demonstrated efficacy, clinical manageability, and cost effectiveness as a single-modality approach, reducing the need for additional interventions.
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