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Unmasking cancer's hidden nerve route with patient-derived organoids
Kevin M Waters1, Akil Merchant2, De-Chen Lin3
1Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Cell Stem Cell
|October 3, 2025
Abstract:
Chan et al.1 show that enteric neurons influence lipid metabolism in gastric cancer organoids, affecting dependencies on key enzymes. Using CRISPR screening and metabolic analysis, their work highlights how microenvironmental signals impact tumor metabolism and potential treatment targets in gastric cancer.
