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From sentinels to engineers: The future of microglia in brain regeneration
1Department of Cell Biology and Neuroscience, Rutgers University-New Brunswick, Piscataway, NJ 08854, USA.
Cell Stem Cell
|October 3, 2025
Abstract:
Recent studies highlight microglial replacement as a promising therapeutic approach for neurological disease. Wu et al.1 demonstrated that transplanted bone marrow-derived cells halted ALSP progression, while Mader et al.2 introduced a strategy that avoids systemic bone marrow ablation toxicity and reduces immune rejection, collectively validating this strategy's therapeutic potential.
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