Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.4K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.9K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.9K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.5K
The Extracellular Matrix01:29

The Extracellular Matrix

11.9K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
11.9K
The Extracellular Matrix01:42

The Extracellular Matrix

88.2K
Overview
88.2K
Cell Migration01:19

Cell Migration

6.4K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting fibroblast TXNDC5 resolves tumor desmoplasia and PD-1 resistance in colorectal cancer with mesenchymal traits.

Nature communications·2026
Same author

DP103 as a critical modulator of Wnt signaling and cancer stemness: implications for precision treatment in triple negative breast cancer.

Cell death & disease·2026
Same author

Recurrence in the chemotherapy regimen of bladder carcinoma originates from quiescent epidermoid-like cells.

Nature communications·2026
Same author

World Ovarian Cancer Day: unravelling the molecular anatomy of a silent killer.

Singapore medical journal·2026
Same author

Epithelial-mesenchymal plasticity in breast cancer: from cell states to clinical vulnerability.

Trends in cancer·2026
Same author

Amniogenesis in embryos and stem cell models.

Nature cell biology·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
See all related articles

Related Experiment Video

Updated: Jan 16, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

36.5K

Epithelial-mesenchymal transition.

Cecilia Xi Zhang1, Ruby Yun-Ju Huang2, Guojun Sheng3

  • 1Biosyngen Pte Ltd, Tai Seng Exchange, Singapore 536671, Singapore.

Cell
|October 3, 2025
PubMed
Summary
This summary is machine-generated.

Epithelial-mesenchymal transition (EMT) is a conserved process in development and disease. Understanding EMT

Keywords:
carcinomaepithelial-mesenchymal transitionfibrosisgastrulationinitiationmetazoansminimal residual diseaseprogressionrecurrencesresistancetherapieswound healing

More Related Videos

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.8K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.2K

Related Experiment Videos

Last Updated: Jan 16, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

36.5K
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.8K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

14.2K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Cancer Biology

Background:

  • Epithelial-mesenchymal transition (EMT) is a fundamental process in metazoan development.
  • EMT involves cells transitioning through intermediate states, rarely reaching a fully mesenchymal phenotype.
  • This plasticity is crucial for morphogenetic movements like gastrulation.

Purpose of the Study:

  • To provide an in-depth review of Epithelial-mesenchymal transition (EMT).
  • To explore EMT's role in development, tissue repair, and diseases like cancer.
  • To discuss recent controversies and identify new therapeutic intervention opportunities.

Main Methods:

  • Literature review and synthesis of existing research on EMT.
  • Analysis of molecular mechanisms driving EMT (signaling, metabolism, epigenetics).
  • Examination of EMT's reactivation in adult tissues and its implications in pathology.

Main Results:

  • EMT is a multi-stage, evolutionarily conserved process critical for development.
  • EMT is reactivated in adult tissues, contributing to repair, fibrosis, and cancer progression.
  • Multiple EMT states within tumors create a dynamic ecosystem influencing stemness, invasion, and metastasis.

Conclusions:

  • EMT is a versatile mechanism with significant roles in both normal development and disease.
  • Understanding the complexities of EMT offers potential for novel therapeutic strategies.
  • Further exploration of EMT's functions in tissue repair and cancer is warranted.