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Serum Creatinine and Cystatin C-Derived Indices Suggesting Future Deterioration in Muscular Function, Physical
Ryota Matsuzawa1, Koutatsu Nagai1, Kanae Takahashi2
1Department of Physical Therapy, School of Rehabilitation, Hyogo Medical University, Kobe, Japan.
Objectives:
Serum biomarkers, particularly serum creatinine and cystatin C, have garnered increased attention as a potential method for predicting future declines in muscle strength. Nevertheless, there is currently a dearth of research in this area. We evaluated the association of serum creatinine and cystatin C-derived indices with the subsequent decline in lower extremity muscle strength among community-dwelling older adults.
Design:
A prospective observational study.
Setting And Subjects:
Community-dwelling older individuals (aged ≥65 years) residing in the Sasayama-Tamba area of Japan.
Predictor:
Five indices based on serum creatinine, and cystatin C, including the total body muscle mass index (TBMM), were computed.
Main Outcome:
Changes in muscular function including isometric knee extensor strength and handgrip strength, physical performance, and frailty status, underwent assessments at baseline and 2 years.
Results:
The final dataset comprised 528 community-dwelling older adults (72 [68, 76] years, 65.7% women). The median change and the proportion of individuals experiencing a significant decline in isometric knee extensor strength over a 2-year period were -37.4 N and 40.2%, respectively. total body muscle mass index showed significant associations with the subsequent decline in isometric knee extensor strength, handgrip strength, and frailty status.
Conclusions:
This study demonstrates the association between serum creatinine and cystatin C-derived index, total body muscle mass index, and the subsequent decline in lower extremity muscle strength among older adults. Utilizing markers derived from serum creatinine and cystatin C enables prompt assessment of the need for proactive measures and may facilitate initiating these interventions at a suitable juncture for older individuals.
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