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Related Experiment Video

Updated: Jan 16, 2026

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

Spatial coding dysfunction and network instability in the aging medial entorhinal cortex.

Charlotte S Herber¹, Karishma J B Pratt², Jeremy M Shea²

¹Department of Neurobiology, Stanford University School of Medicine, Stanford, CA, USA. csh47@stanford.edu.

Nature Communications

|October 3, 2025

Summary

This summary is machine-generated.

Aging impairs spatial memory by disrupting the medial entorhinal cortex (MEC). Aged mice showed unstable grid cell firing and altered gene expression linked to memory deficits.

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Last Updated: Jan 16, 2026

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Published on: October 13, 2016

Area of Science:

Neuroscience
Aging Research
Cognitive Decline

Background:

Spatial memory decline is common in aging across species.
The medial entorhinal cortex (MEC) is crucial for spatial memory.
Cellular and network-level spatial coding in aged MEC remains poorly understood.

Purpose of the Study:

To investigate the integrity of cellular and network-level spatial coding in the aged MEC.
To identify molecular changes in the aged MEC correlated with spatial memory deficits.

Main Methods:

In vivo electrophysiology in young, middle-aged, and aged mice navigating virtual environments.
Analysis of spatial firing patterns of MEC grid cells.
Transcriptomic analysis of aged MEC tissue.

Main Results:

Aged MEC grid cells exhibited impaired stabilization of context-specific spatial firing, correlating with memory deficits.
Aged grid networks showed unstable firing patterns with poor context alignment.
Differential gene expression in aged MEC, including interneuron-enriched genes related to synaptic plasticity, correlated with spatial coding quality.

Conclusions:

Aging leads to coordinated transcriptomic, cellular, and network changes in the MEC.
These MEC alterations are implicated in the decline of spatial memory during aging.