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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Related Experiment Video

Updated: Jan 16, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
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A Novel Felbinac Transdermal Patch with High Permeability: Design, Development and Evaluation.

Li Qin1, Cheng Liu1, Ran Bai1

  • 1Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.

AAPS Pharmscitech
|October 3, 2025
PubMed
Summary

This study developed a novel felbinac transdermal patch using propylene glycol as a penetration enhancer. The new patch significantly improved felbinac delivery and showed promising stability and safety for clinical use.

Keywords:
in vitro permeationfelbinactissue distributiontransdermal patch

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Dermatology

Background:

  • Felbinac is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief.
  • Transdermal drug delivery offers advantages over oral administration, including sustained release and reduced systemic side effects.
  • Improving the efficiency of transdermal felbinac delivery is crucial for enhanced therapeutic outcomes.

Purpose of the Study:

  • To design and optimize a novel felbinac transdermal patch with enhanced delivery efficiency.
  • To evaluate the adhesion, in vitro release, stability, and safety of the developed patch.
  • To assess the in vivo tissue distribution of felbinac delivered via the novel patch.

Main Methods:

  • A novel felbinac transdermal patch was prepared using a calendar coating method.
  • Chemical penetration enhancers, including propylene glycol (PG), were screened to optimize transdermal delivery.
  • In vitro transdermal release, adhesion, stability (4 months), skin irritation, and in vivo tissue distribution studies were conducted.

Main Results:

  • The optimized patch with 1% PG achieved a cumulative transdermal amount of 189.03 μg/cm² in 12 hours, doubling that of the commercial SELTOUCH® patch.
  • The transdermal patch demonstrated high adhesion, stable permeability over 4 months, and good safety (no significant skin irritation).
  • In vivo studies showed significantly increased felbinac concentrations in plasma, skin, and muscle tissues compared to the commercial product.

Conclusions:

  • The developed felbinac transdermal patch exhibits high adhesion, superior transdermal delivery efficiency, and excellent stability.
  • The novel patch represents a promising transdermal drug delivery system with significant potential for clinical applications in pain management.