A Novel Felbinac Transdermal Patch with High Permeability: Design, Development and Evaluation
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Updated: Jan 16, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
1Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.
Abstract:
The objective of the work was to design a novel felbinac transdermal patch to improve its transdermal delivery efficiency by adding chemical penetration enhancers. The adhesion properties and in vitro transdermal release performance were first evaluated. The transdermal stability and skin irritation were then evaluated. Moreover, in vivo tissue distribution was also examined. The novel felbinac transdermal patch with high adhesion was prepared by calendar coating method. Different types of chemical enhancers and their amount on in vitro transdermal delivery efficiency were systematically screened. In vitro transdermal release experiments showed that by adding 1% propylene glycol (PG) as penetration enhancers, the cumulative transdermal amount of the transdermal patch within 12 h was 189.03 μg/cm2, which was twice that of commercial product SELTOUCH® (94.44 μg/cm2). In addition, the transdermal patch still maintained stable permeability after being stored at room temperature for 4 months and also had good safety. Further, in vivo experiments confirmed that the concentration of felbinac in plasma, skin, and muscle tissues was significantly increased following administration of the self-made transdermal patch compared to SELTOUCH®. In conclusion, the felbinac transdermal patch developed in this study demonstrated high adhesion, excellent transdermal delivery efficiency and good stability, representing a transdermal drug delivery system with great clinical application potential.
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