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C-reactive protein-triglyceride glucose index predicts mortality in cardiovascular-kidney-metabolic syndrome stage
Qianliang Ying1, Fan He2,3,4, Lunzhe Wu2,3,4
1Department of Cardiology, Ninghai First Hospital, Ningbo, China.
Insights
A higher C-reactive protein-triglyceride glucose index (CTI) score is linked to increased mortality risk in early cardiovascular-kidney-metabolic (CKM) syndrome. This association is more pronounced in younger individuals, highlighting CTI as a significant predictor.
Area of Science:
- Cardiology
- Nephrology
- Metabolic Health
- Biomarkers
- Public Health
Background:
- Cardiovascular-kidney-metabolic (CKM) syndrome involves interconnected metabolic, kidney, and cardiovascular diseases.
- The C-reactive protein-triglyceride glucose index (CTI) measures inflammation and insulin resistance.
- The prognostic value of CTI in early-stage CKM syndrome remains unclear.
Purpose of the Study:
- To investigate the association between the CTI score and mortality risk in individuals with early-stage CKM syndrome.
- To determine if CTI predicts all-cause and cardiovascular disease (CVD) mortality.
- To explore potential age-related differences in this association.
Main Methods:
- Analysis of National Health and Nutrition Examination Survey data (1999-2010).
- Utilized multivariable Cox proportional-hazards models.
- Vital status tracked via National Death Index linkage through December 31, 2019.
Main Results:
- A total of 1783 deaths (491 from CVD) occurred among 10,718 participants over a mean 14.0-year follow-up.
- Higher CTI scores were independently associated with increased all-cause mortality (HR 1.56) and CVD mortality (HR 2.03).
- The association between CTI and all-cause mortality was significantly stronger in participants younger than 60.
Conclusions:
- Elevated CTI scores are independently linked to higher all-cause and CVD mortality in early CKM syndrome.
- The CTI score serves as a valuable prognostic biomarker in this population.
- Younger individuals with early CKM syndrome and higher CTI scores face a greater mortality risk.
Background:
Cardiovascular-kidney-metabolic (CKM) syndrome is defined by the interplay of metabolic risk factors, chronic kidney disease, and cardiovascular disease. The C-reactive protein-triglyceride glucose index (CTI) is a composite biomarker that reflects both inflammation and insulin resistance, but whether it is associated with mortality in persons with early-stage CKM syndrome is unknown.
Methods:
We analyzed data from the National Health and Nutrition Examination Survey from 1999 to 2010. We used multivariable Cox proportional-hazards models to assess the association between the CTI score and the risk of all-cause mortality and cardiovascular disease (CVD) mortality, with vital status ascertained through Linkage to the National Death Index through December 31, 2019.
Results:
Among 10,718 participants, a total of 1783 deaths (491 from CVD) occurred during a mean follow-up of 14.0 years. In fully adjusted models, a higher CTI score was associated with a greater risk of all-cause mortality (HR per unit increase, 1.56; 95% CI, 1.36 to 1.78) and of CVD mortality (HR per unit increase, 2.03; 95% CI, 1.49 to 2.77). The association with all-cause mortality was stronger among participants under the age of 60 than among those over 60 years old (P < 0.001 for interaction).
Conclusion:
Our study found that in patients with early-stage CKM syndrome, a higher CTI was independently associated with an increased risk of all-cause mortality and CVD mortality. This association was more significant in younger participants.
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