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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Microbiome-Based Interventions for Skin Aging and Barrier Function: A Comprehensive Review.

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  • 1Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

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The skin microbiome is crucial for skin health, but aging and external factors disrupt it. Microbiome-supportive skincare using probiotics, prebiotics, and postbiotics can restore balance and combat skin aging.

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Area of Science:

  • Dermatology and Microbiology: Investigating the complex interactions within the skin's microbial ecosystem and its impact on skin physiology and health.

Background:

  • The skin microbiome, a diverse community of microorganisms, is vital for skin barrier function, immunity, and pathogen defense.
  • Factors like pollution, harsh products, and aging disrupt this balance, leading to compromised skin health and accelerated aging, characterized by reduced diversity and increased inflammation (inflammaging).

Purpose of the Study:

  • To explore the role of the skin microbiome in aging and the potential of microbiome-supportive skincare to counteract these effects.
  • To highlight the mechanisms by which probiotics, prebiotics, and postbiotics can restore microbial balance and enhance skin health.

Main Methods:

  • Review of current literature on skin microbiome dynamics, aging processes, and the impact of external factors.
  • Analysis of the therapeutic potential of microbiome-supportive skincare ingredients (probiotics, prebiotics, postbiotics).

Main Results:

  • Microbiome disruption contributes significantly to skin aging and inflammation.
  • Microbiome-supportive skincare demonstrates potential in restoring microbial balance, strengthening the skin barrier, and reducing inflammation.

Conclusions:

  • Microbiome-supportive skincare offers a promising avenue for maintaining skin health and combating aging by modulating the skin's microbial ecosystem.
  • Further research, including personalized approaches and advanced diagnostics, is needed to optimize these interventions for diverse populations.