Mechanochemically controllable synthesis of mono- or di-alkenylated indolizines
Yue Yu1, Ning Guan1, Chunying Zhao1
1School of Chemistry and Chemical Engineering, Guangdong Cosmetics Engineering & Technology Research Center, Guangdong Pharmaceutical University, Zhongshan 528458, China. caohua@gdpu.edu.cn.
Abstract:
We report the synthesis of a series of alkylated indolizine derivatives from indolizine and p-QMs under ball-milling conditions. This method offers a controllable approach to synthesize mono- or di-alkenylated indolizines through modulation of substrate ratios, acid additives, and oxidant types. This procedure is solvent-free and operationally simple, and exhibits broad substrate tolerance, high conversion efficiency, and excellent scalability, making it both practical and versatile.
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