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Anti-neoangiogenic nanodelivery systems: advances in tumor-based and ophthalmic disease research

Bingjie Guo1, Zhaokai Li1, Junyi Zhou1

  • 1Inner Mongolia Medical University, No. 5, Xinhua Road, Hohhot, Inner Mongolia 010059, China. 17771564957@163.com.

Journal of Materials Chemistry. B
|October 4, 2025
PubMed

Insights

Nanodrug delivery systems offer improved anti-angiogenic therapy for tumors and eye diseases by overcoming limitations of traditional drugs. These systems enhance precise delivery and drug efficacy.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Abnormal neovascularization is central to diseases like cancer and ophthalmic conditions.
  • Anti-angiogenic drugs are key therapies but have limitations including toxicity and resistance.
  • Nanodrug delivery systems present advantages for anti-angiogenic therapy.

Purpose of the Study:

  • To review advances in nanodrug delivery systems for anti-angiogenic therapy.
  • To summarize mechanisms, delivery strategies, and applications in tumors and ophthalmic diseases.
  • To discuss functionalized and combination nanotherapies for anti-angiogenesis.

Main Methods:

  • Literature review of recent research on nanodrug delivery systems.
  • Analysis of nanocarrier strategies for precise and sustained drug release.
  • Focus on functionalized and combination nanodrug approaches.

Main Results:

  • Nanodrug systems show promise in overcoming limitations of conventional anti-angiogenic drugs.
  • Targeted delivery and sustained release improve therapeutic outcomes.
  • Functionalized and combination nanotherapies offer enhanced anti-angiogenic potential.

Conclusions:

  • Nanodrug delivery systems represent a significant advancement in treating neovascularization-related diseases.
  • Further research into functionalized and combination nanotherapies is warranted.
  • Addressing challenges will optimize nanomedicine for anti-angiogenic applications.

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