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Updated: Jul 16, 2026
![Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62460.jpg&w=3840&q=50)
Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
An Insight Into Adipose Tissue Thermogenesis Regulated by N6-Methyladenosine: Mechanisms and Therapeutic Implications
Yuan-Hai Sun1, Ya-Qian Feng1, Sun-Ying Cheng1
1Institute of Pharmacology, Zhejiang University of Technology, Hangzhou, China.
None:
Adipose tissue thermogenesis, both uncoupling protein 1 (UCP1)-dependent and independent thermogenesis, plays a critical role in the homeostasis of whole-body metabolism. Emerging evidence demonstrates that key nodes in adipose tissue thermogenesis can be regulated by dynamic and reversible N6-methyladenosine (m6A) modification, which is one of the most prevalent and extensively studied RNA modifications. Furthermore, its dysregulation drives the pathogenesis of obesity and related metabolic disorders. In this review, we elucidate the role and molecular mechanisms of m6A modification in adipose tissue thermogenesis, highlight potential therapeutic strategies for promoting thermogenic remodeling of adipose tissue through targeting m6A modification, and discuss future research directions in this field. The insights provide clues for translational research aimed at developing m6A-based therapies for metabolic diseases.
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