Related Experiment Video
Updated: Jan 16, 2026

Confocal Time Lapse Imaging as an Efficient Method for the Cytocompatibility Evaluation of Dental Composites
Published on: November 9, 2014
Decoding Dissolution-Solubility Comparison of Bioceramic-coated and Conventional Gutta-percha Cones across Solvents
Tanya Arora1, Surya Dahiya2, Sanchita Khandelwal3
1Department of Conservative Dentistry & Endodontics, Maharishi Markandeshwar College of Dental Sciences and Research, Ambala, Haryana, India, e-mail: tarora999@gmail.com, Orcid: https://orcid.org/0009-0006-4671-6444.
Aim:
To evaluate the solubility of bioceramic-coated and conventional gutta-percha (GP) in various organic and traditional solvents at two time intervals.
Materials And Methods:
This in vitro study used 200 ISO-standardized size 35, taper 6% GP cones (100 bioceramic-coated, 100 conventional), divided into five solvent groups: xylene, orange oil, castor oil, peppermint oil, and distilled water (control). Cones were immersed for 5 and 10 minutes. Pre- and postimmersion weights were measured using a digital weighing balance at two different time intervals, and the difference was used to assess solubility.
Results:
Xylene demonstrated the highest solubility for both GP types. Orange oil was moderately effective on bioceramic-coated cones, while castor and peppermint oils showed minimal effect. For conventional GP, solvent efficacy followed the order: orange oil > peppermint oil > castor oil.
Conclusion:
Xylene remains the most effective solvent, though its toxicity raises concerns. Organic solvents, particularly orange oil, offer safer alternatives, but their effectiveness varies with the type of GP.
Clinical Significance:
Solubility differences between bioceramic-coated and conventional GP impact retreatment efficiency. While xylene remains most effective, orange oil provides a biocompatible alternative, particularly effective against conventional GP, supporting safer and more targeted solvent selection in clinical practice. How to cite this article: Arora T, Dahiya S, Khandelwal S, et al. Decoding Dissolution-Solubility Comparison of Bioceramic-coated and Conventional Gutta-percha Cones across Solvents and Two Different Time Intervals: An In Vitro Study. J Contemp Dent Pract 2025;26(7):639-644.
Related Concept Videos
In Vitro Drug Dissolution: Alternative Methods
In Vitro Drug Dissolution: Compendial Testing Models I
In Vitro Drug Dissolution: Compendial Testing Models II
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Drug Dissolution: Requirements and Profile Comparison
Factors Influencing Drug Absorption: Drug Dissolution

