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The diagnostic pitfall of sIL-2R in hemophagocytic lymphohistiocytosis: A key marker lost in analytic translation

The diagnostic pitfall of sIL-2R in hemophagocytic lymphohistiocytosis: A key marker lost in analytic translation

Josia Fauser ¹, Werner Klotz ², Manuel Trebo ¹, Andreas Pircher ¹, Sieghart Sopper ¹, Dominik Wolf ¹, Günter Weiss ², David Haschka ²

Josia Fauser ¹, Werner Klotz ², Manuel Trebo ¹

¹Department of Internal Medicine V, Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Austrian Comprehensive Cancer Network, Innsbruck, Austria.
²Department of Internal Medicine II, Infectious Diseases, Immunology, and Rheumatology, Medical University of Innsbruck, Innsbruck, Austria.

⁰Department of Internal Medicine V, Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Austrian Comprehensive Cancer Network, Innsbruck, Austria.

The Journal of Allergy and Clinical Immunology +

|

October 4, 2025

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Summary

No abstract available on PubMed

Keywords:

Biomarker HLH laboratory sIL-2R

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Leaky Scanning

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...

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