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Poly(glycerol sebacate): A Comparative Study of Various Synthesis Methods.

Silke Andrä-Żmuda1, Paweł Chaber1, Magdalena Martinka Maksymiak1

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Enzymatic synthesis using Candida antarctica lipase B (CALB) offers superior control for producing poly(glycerol sebacate) (PGS) prepolymers with enhanced molecular weight and dispersity, preventing gelation.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Enzymatic Synthesis

Background:

  • Poly(glycerol sebacate) (PGS) is a promising biodegradable elastomer for biomedical applications.
  • Optimizing PGS synthesis is crucial for controlling its properties and performance.

Purpose of the Study:

  • To compare five distinct synthesis methods for poly(glycerol sebacate) (PGS) prepolymers.
  • To evaluate the impact of synthesis strategy on PGS molecular architecture and physicochemical properties.

Main Methods:

  • Comparative analysis of five PGS synthesis routes: high-temperature polycondensation, reduced pressure polycondensation, enzymatic synthesis with Candida antarctica lipase B (CALB), CALB with acetone, and Amberlyst-15 catalysis.
  • Characterization of PGS prepolymers using FTIR, NMR, ESI-MS, GPC, DSC, and TGA.

Main Results:

  • Enzymatic synthesis with CALB demonstrated superior reaction control, prevented gelation, and yielded higher molecular weight PGS with narrow dispersity.
  • NMR and ESI-MS analyses confirmed the presence of both linear and branched PGS structures.
  • Synthesis strategy significantly impacts the molecular architecture and properties of PGS prepolymers.

Conclusions:

  • Enzymatic synthesis using CALB is the most effective method for producing well-defined PGS prepolymers.
  • The findings provide a foundation for designing tailored PGS-based materials for biomedical applications.