Human Papillomavirus Genotype Distribution in Penile Cancer: Clinical, Histopathological, Radiological Correlations, and Public Health Perspectives
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View abstract on PubMed
Summary
This summary is machine-generated.Human papillomavirus (HPV) significantly contributes to penile cancer, with HPV 16 being the most common type. This highlights the need for HPV vaccination to reduce cancer incidence.
Area Of Science
- Oncology
- Virology
- Epidemiology
Background
- Human papillomavirus (HPV) is implicated in various cancers, including penile cancer.
- Geographical variations in HPV prevalence necessitate region-specific research.
- Understanding HPV genotypes is vital for targeted screening and vaccination strategies.
Purpose Of The Study
- To determine the prevalence of HPV genotypes in penile carcinoma cases.
- To correlate HPV genotype prevalence with histopathological, clinical, and radiological parameters.
- To identify risk factors associated with HPV infection in penile cancer.
Main Methods
- Real-time multiplex polymerase chain reaction (PCR) was used for HPV detection.
- Biopsy samples from 27 penile carcinoma patients were analyzed.
- Statistical analysis was performed to correlate HPV findings with clinical data.
Main Results
- HPV was detected in 74.1% of penile carcinoma cases.
- Multiple HPV subtypes were found in 75% of infected patients.
- HPV 16 was the predominant genotype (75%), often with coinfections.
Conclusions
- A high prevalence of HPV, particularly HPV 16, was observed in penile carcinoma in Assam.
- Multiple sexual partners emerged as a significant risk factor for HPV infection.
- Vaccination against high-risk HPV genotypes is recommended to mitigate HPV-related malignancies.
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