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  1. Home
  3. Correlation Between Ttf-1 Expression And Egfr Mutations In Moroccan Lung Adenocarcinoma: A Prospective Six-year Study.
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  3. Correlation Between Ttf-1 Expression And Egfr Mutations In Moroccan Lung Adenocarcinoma: A Prospective Six-year Study.

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Correlation between TTF-1 expression and EGFR mutations in moroccan lung adenocarcinoma: A prospective six-year

Sara Boukansa1, Ismail Mouhrach2, Fatima El Agy1

  • 1Laboratory of Biomedical and Translational Research, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco; Laboratory of Anatomic Pathology and Molecular Pathology, University Hospital Hassan II, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

Cancer Treatment and Research Communications
|October 4, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Thyroid transcription factor-1 (TTF-1) expression strongly correlates with epidermal growth factor receptor (EGFR) mutations, particularly exon 19 deletions, in Moroccan lung adenocarcinoma patients. This finding supports their use as complementary biomarkers for personalized treatment strategies.

Keywords:
EGFR mutationExon 19Exon 21NSCLCTTF-1

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • Lung adenocarcinoma is a leading cause of cancer mortality globally.
  • Personalized treatment requires predictive biomarkers for improved patient outcomes.
  • Thyroid transcription factor-1 (TTF-1) and epidermal growth factor receptor (EGFR) are key players in lung cancer development.

Purpose of the Study:

  • To investigate the correlation between TTF-1 expression and EGFR mutations in Moroccan lung adenocarcinoma patients.
  • To assess the potential of TTF-1 and EGFR as complementary diagnostic and therapeutic biomarkers.
  • To analyze the association of these biomarkers with clinicopathological parameters and survival.

Main Methods:

  • Prospective enrollment of 234 lung adenocarcinoma patients (2017-2022).
  • Immunohistochemistry for TTF-1 expression analysis.
  • Molecular testing for EGFR mutation detection (including exon 19 deletions and exon 21 mutations).
  • Statistical analysis of associations with clinicopathological data and overall survival.

    • Main Results:

    • TTF-1 expression was observed in 83.8% of cases, higher in females and never-smokers.
    • EGFR mutations were found in 21.36% of patients; exon 19 deletions were most common (15.38%).
    • A significant association was found between TTF-1 expression and EGFR mutations (p < 0.001), especially exon 19 deletions (p = 0.009).

    Conclusions:

    • TTF-1 expression is strongly correlated with common EGFR mutations, particularly exon 19 deletions, in Moroccan lung adenocarcinoma.
    • The association is most pronounced in never-smokers, highlighting TTF-1 and EGFR as complementary biomarkers.
    • Further multicenter studies are recommended to validate their prognostic significance and guide treatment decisions.