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Sleep abnormalities in mouse models of depression: a systematic review
Alberto Potenzieri1, Andrea Escelsior2, Gianluca Serafini2
1Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy; Brain Development and Disease Laboratory, Istituto Italiano di Tecnologia, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Sleep Medicine Reviews
|October 4, 2025
Summary
Mouse models of major depressive disorder (MDD) show increased rapid eye movement (REM) sleep and non-REM (NREM) sleep fragmentation, validating their use in studying sleep disturbances.
Area of Science:
- Neuroscience
- Sleep Medicine
- Psychiatry
Background:
- Sleep disturbances are common in major depressive disorder (MDD), worsening symptoms.
- Existing research well-describes human sleep features in MDD but lacks comprehensive data on animal models.
- Understanding sleep alterations in mouse models is crucial for validating their use in MDD research.
Conclusions:
- Mouse models exhibit key sleep disturbances relevant to MDD, confirming their utility.
- This review provides a resource for researchers studying sleep alterations in MDD using animal models.
- Further research is needed to clarify sleep deprivation responses and power spectrum data in these models.
