Related Experiment Video
Updated: Jul 12, 2026

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat
Published on: April 23, 2018
Pseudomonas guariconensis Necrotizing soft tissue infection, Denmark
Sofus Rønne Soltau1, Nina Elisabeth Pontoppidan Monrad2, Allan Evald Væver Nielsen3
1Hvidovre Hospital, Department of Clinical Microbiology, Denmark.
Abstract:
We describe the first published case report of a successful treatment of Pseudomonas guariconensis-induced Necrotizing Soft Tissue Infection (NSTI). Since Pseudomonas guariconensis has been resistant to meropenem in all reported cases, clinicians and microbiologists should treat these patients with extreme care.
Patient And Methods:
A 72-year-old man presented to the emergency department with a 3-day history of fever, pain in the right leg/foot and general malaise. He was diagnosed with NSTI, empirical meropenem and clindamycin was started, and surgery was quickly performed with removal of all dead skin and subcutaneous tissue. All fasciae were intact.
Results:
Blood cultures and tissue samples showed growth of Pseudomonas guariconensis, which a literature review revealed to be highly suspicious of meropenem resistance. This prompted quick change of antibiotics, first with ciprofloxacin and metronidazole added and then change of meropenem to cefiderocol. Susceptibility tests on both blood and tissue samples revealed resistance to meropenem (along with resistance to many other antibiotics). The patient improved, was changed to ceftazidim and ciprofloxacin and recovered fully from the infection.
Conclusions:
Since clindamycin has no effect on any Pseudomonas species and since Pseudomonas guariconensis has been resistant to meropenem in all reported cases, clinicians and microbiologists should treat these patients with extreme care.
Insights
This case report details the successful treatment of Necrotizing Soft Tissue Infection (NSTI) caused by Pseudomonas guariconensis. Due to meropenem resistance, alternative antibiotics were crucial for patient recovery.
Area of Science:
- Infectious Diseases
- Microbiology
- Surgical Infections
Background:
- Necrotizing Soft Tissue Infection (NSTI) is a severe condition requiring prompt intervention.
- Pseudomonas species, including P. guariconensis, can cause aggressive infections.
- Meropenem resistance in P. guariconensis has been previously reported, posing treatment challenges.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Gene Regulation in Microbial Communities: Quorum Sensing
Atypical Pneumonia

