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Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
Published on: November 17, 2023
Development of dual-dummy template molecularly imprinted polymer embedded with Ag nanoparticles for sensitive and
Wenlei Zhai1, Mingshuo Cao1, Dizhe Wei1
1Institute of Quality Standard and Testing Technology, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Abstract:
Fumonisin B1 (FB1) is the most toxic and common form of fumonisins. Exposure to FB1 can lead to various harmful effects on human and livestock health. Herein, an FB1 sensor was developed by combining molecularly imprinted polymer (MIP) technique with surface-enhanced Raman spectroscopy (SERS). A dual-dummy template strategy was developed for MIP synthesis by employing succinic acid and d-sphingosine as the analogs of FB1. The MIP-SERS method was established based on a sensor composed of Ag nanoparticles encapsulated by the MIP. Signal amplification was achieved through the competitive displacement of the Raman tag by FB1. SERS detection of FB1 with a detection limit of 15 ng mL-1 was achieved. Detecting FB1 in cereals was demonstrated via spiked and real sample measurements, with recovery rates of 89.2 % - 120.2 %. This study demonstrated the synthesis of MIP using the dual-dummy template strategy and its application in the rapid detection of FB1.
