Link between triglyceride-glucose-body mass index and future cardiovascular disease risk in Chinese menopausal women: A nationwide prospective cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.The triglyceride glucose-body mass (TyG-BMI) index is linked to increased cardiovascular disease (CVD) risk in postmenopausal women. This index can aid in developing better CVD prevention strategies for this demographic.
Area Of Science
- Endocrinology
- Cardiology
- Public Health
Background
- The relationship between the triglyceride glucose-body mass (TyG-BMI) index and cardiovascular disease (CVD) risk in postmenopausal women is not well-established.
- Targeted risk assessment tools for CVD in this population are needed.
Purpose Of The Study
- To investigate the association between the TyG-BMI index and CVD risk in Chinese menopausal women.
- To evaluate the TyG-BMI index's potential as a biomarker for CVD risk assessment.
Main Methods
- Utilized data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 and 2020.
- Employed multivariable logistic regression and restricted cubic spline (RCS) regression to analyze the association and nonlinearity.
- Conducted stratified analyses to examine effect modification by subgroups.
Main Results
- A significant association was found between higher TyG-BMI and increased CVD risk (OR = 1.28 per IQR increase).
- A linear dose-response relationship between TyG-BMI and CVD risk was observed.
- TyG-BMI demonstrated superior predictive performance for CVD compared to the TyG index (AUC = 0.645 vs. 0.622).
Conclusions
- The TyG-BMI index is significantly associated with CVD risk in postmenopausal women.
- TyG-BMI can serve as a valuable biomarker for improving primary prevention and management of CVD in this population.
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