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Prognostic impact of serum triglycerides in acute pancreatitis: Evidence from multi-center cohort study using a
Da Hee Park1, Seung In Seo2, Jin Gu Kang1
1Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Background And Aims:
Hypertriglyceridemia (HTG) is a risk factor for acute pancreatitis (AP); however its association with increased AP severity remains unclear. This study aimed to investigate the association between HTG levels and severity of AP.
Design:
This study analyzed data from 10 Korean hospital databases converted to a common data model from 2004 to 2019. Hospitalized patients with AP were divided into two groups based on their serum triglyceride (TG) levels: a high TG (HiTG) group (serum TG: >500 mg/dL) and a low TG (LoTG) group (TG: ≤500 mg/dL). Subgroup analyses were performed based on age and sex.
Results:
A total of 5644 AP patients were included in the study, with 534 and 5110 patients in the HiTG and LoTG groups, respectively. An increasing trend was observed in the number of patients with pancreatitis (p < 0.001 for trend), including those with HTG-associated pancreatitis. The HiTG group showed a male predominance (74.9 %), and 34.4 % of patients were between the ages of 30 and 39 years. The HiTG group showed significantly higher C-reactive protein (CRP) elevation rates (30.8 % vs. 10.6 %, P < 0.001) requiring intensive care unit (ICU) admission (12.8 % vs. 9.3 %, P = 0.050) than the LoTG group. Age-based subgroup analysis revealed that the HiTG group had significantly higher CRP levels, ICU management, and 30-day mortality in patients aged <60 years.
Conclusion:
HTG is associated with a higher risk of developing severe AP. Younger patients (<60 years) with HTG may be vulnerable to a more severe disease course.
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