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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Exoskeleton assistance optimization for Charcot-Marie-Tooth patients based on customized forward predictive

Yiying Peng1,2,3, Fengchao Zhang1,2,3, Liping Wang1,2,3

  • 1College of Artificial Intelligence, Nankai University, Tianjin, PRC.

Computer Methods in Biomechanics and Biomedical Engineering
|October 5, 2025
PubMed
Summary

This study optimized ankle assistance for Charcot-Marie-Tooth (CMT) patients using computer simulations. The personalized approach reduced energy use and muscle activity during walking.

Keywords:
Charcot-Marie-Toothexoskeleton assistancemusculoskeletal modelpredictive simulation

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Area of Science:

  • Biomedical Engineering
  • Neuromuscular Disorders
  • Rehabilitation Robotics

Background:

  • Charcot-Marie-Tooth (CMT) disease leads to gait impairments, notably foot-drop, impacting mobility.
  • Current powered orthoses offer variable effectiveness in assisting CMT patients.
  • Personalized assistive strategies are needed to improve gait in CMT.

Purpose of the Study:

  • To optimize ankle torque assistance for Charcot-Marie-Tooth patients using patient-specific musculoskeletal models and forward predictive simulation.
  • To evaluate the impact of optimized assistance on simulated metabolic cost and muscle activity.

Main Methods:

  • Developed customized musculoskeletal models based on gait data from CMT patients.
  • Employed forward predictive simulation to optimize ankle assistive torque profiles.
  • Validated simulation accuracy through patient-specific model customization.

Main Results:

  • The optimized assistive torque profile significantly reduced simulated metabolic cost by 9.9% compared to normal walking.
  • Soleus and gastrocnemius muscle activity was substantially decreased with the optimized assistance.
  • Patient-specific model customization improved simulation accuracy for predicting gait mechanics.

Conclusions:

  • A simulation framework using customized musculoskeletal models can effectively optimize exoskeleton assistance for CMT.
  • Personalized ankle torque assistance shows potential for reducing energy expenditure and muscle strain in CMT patients.
  • This approach offers valuable guidance for designing advanced assistive devices for neuromuscular disorders.