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A comparative evaluation of two subharmonic-aided pressure estimation (SHAPE) analysis methods.

Hailee Mayer¹, Priscilla Machado², Trang Vu²

¹Thomas Jefferson University, Department of Radiology, Philadelphia, PA, USA; Drexel University, School of Biomedical Engineering, Science, and Health Systems, Philadelphia, PA, USA.

|October 5, 2025

Summary

This summary is machine-generated.

A new ultrasound technique, fast-SHAPE, offers a quicker way to measure portal pressures using ultrasound contrast agents (UCAs). This method may improve diagnostic evaluations for conditions like portal hypertension by providing a safer, faster alternative to invasive procedures.

Keywords:

Portal hypertension SHAPE Subharmonic UCAs Ultrasound

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Area of Science:

Medical Imaging
Ultrasound Technology
Hepatology

Background:

Clinical pressure measurement is vital for diagnosing conditions like portal hypertension.
Current invasive methods like hepatic vein catheterization carry risks and limit measurement frequency.
Ultrasound contrast agents (UCAs) can be used to estimate hydrostatic pressure changes non-invasively.

Purpose of the Study:

To compare the efficacy and utility of the traditional Subharmonic-aided Pressure Estimation (SHAPE) method with a newly proposed faster version, fast-SHAPE.
To evaluate fast-SHAPE's performance in estimating hydrostatic pressure changes in patients.
To explore the potential of fast-SHAPE as a more efficient diagnostic tool.

Main Methods:

Subharmonic-aided Pressure Estimation (SHAPE) utilizes UCAs' nonlinear oscillation and subharmonic emissions under acoustic pressure.
The traditional SHAPE method involves multiple acquisitions to determine subharmonic amplitudes.
The fast-SHAPE method employs an acoustic pressure optimization algorithm for rapid subharmonic amplitude acquisition.

Main Results:

The study compared SHAPE and fast-SHAPE in the same patient cohort.
Analysis focused on the accuracy and efficiency of subharmonic amplitude determination by both methods.
Results will elucidate the clinical utility and potential advantages of the fast-SHAPE technique.

Conclusions:

Fast-SHAPE presents a potentially more efficient approach to ultrasound-based pressure estimation.
This technique could enhance the diagnostic capabilities for portal hypertension and related conditions.
Further validation is needed to confirm fast-SHAPE's clinical applicability and benefits over traditional SHAPE.