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Updated: Jan 16, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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Inhibiting TGF-β signaling pathway for disease therapy: challenges and opportunities

XiaoYan Gao1, XiuDan Li2, CongYing Zhang1

  • 1Key Laboratory of Research on Human Genetic Diseases at Universities of Inner Mongolia Autonomous Region, Basic Medical College, Chifeng University, Chifeng, China; Key Laboratory of Mechanism and Evaluation of Traditional Chinese & Mongolian Medicine, Chifeng University, Chifeng, China.

Cytokine
|October 5, 2025
PubMed

Insights

Transforming growth factor-beta (TGF-β) is crucial for development and homeostasis. Targeting TGF-β signaling offers new therapeutic strategies for diseases like cancer and fibrosis.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Immunology

Background:

  • Transforming growth factor-beta (TGF-β) is a key cytokine involved in numerous cellular processes.
  • The TGF-β signaling pathway plays a vital role in embryonic development, tissue homeostasis, and adult tissue repair.
  • Dysregulation of the TGF-β pathway is implicated in the pathogenesis of various diseases.

Purpose of the Study:

  • To review recent research on the role of TGF-β in disease pathogenesis.
  • To explore the therapeutic potential of targeting the TGF-β signaling pathway.
  • To summarize current treatment strategies involving TGF-β.

Main Methods:

  • Literature review of recent studies on TGF-β.
  • Analysis of TGF-β's role in cancer, fibrosis, and autoimmune diseases.
  • Evaluation of therapeutic interventions targeting TGF-β.

Main Results:

  • TGF-β signaling is essential for normal physiological functions.
  • Aberrant TGF-β signaling contributes to the development of cancer, fibrosis, vascular disorders, and autoimmune conditions.
  • Selective TGF-β inhibitors show promise as therapeutic agents.

Conclusions:

  • Targeting the TGF-β pathway presents a promising therapeutic strategy for multiple diseases.
  • Further development of TGF-β inhibitors could lead to effective clinical treatments.
  • Understanding TGF-β's role is critical for advancing disease treatment.
Keywords:
Clinical drugsDiseasesNonclinical drugsTGF-β inhibitorsToxicity

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