Related Experiment Video

Updated: Jan 16, 2026

Author Spotlight: Enhancing Coronary Artery Revascularization
05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

1.2K

Association of myocardial bridging and LAD length with Takotsubo syndrome: A MINOCA cross-sectional study

Oscar Winnberg1, Jens Jensen2, Shams Y-Hassan3

  • 1Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Cardiology Unit, Södersjukhuset, Stockholm, Sweden.

International Journal of Cardiology
|October 5, 2025
PubMed

Insights

This study found no link between myocardial bridging or left anterior descending artery length and Takotsubo syndrome. These coronary artery variations do not appear to be major factors in developing Takotsubo syndrome.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Medical Imaging

Background:

  • Takotsubo syndrome (TTS) is an acute cardiac condition linked to stress and catecholamine surges.
  • Potential roles of myocardial bridging (MB) and left anterior descending artery (LAD) length in TTS are unclear.
  • Investigating these factors within a myocardial infarction with non-obstructive coronary arteries (MINOCA) cohort is crucial.

Purpose of the Study:

  • To determine if myocardial bridging (MB) or left anterior descending artery (LAD) length are associated with Takotsubo syndrome (TTS).
  • To evaluate these anatomical factors in a well-characterized cohort of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA).

Main Methods:

  • Analysis of 183 participants from the Stockholm Myocardial Infarction with Normal Coronaries (SMINC) 1 and 2 studies.
  • Coronary computed tomography angiography (CCTA) for MB assessment and invasive coronary angiography (ICA) for LAD length measurement.
  • Comparison of 60 TTS patients with 123 MINOCA controls without TTS.

Main Results:

  • Myocardial bridging (MB) prevalence was similar in TTS patients (37%) and controls (42%), with no significant association (p=0.523).
  • Left anterior descending artery (LAD) length did not significantly differ between TTS patients and controls (p=0.088).

Conclusions:

  • No significant association was found between myocardial bridging (MB) or left anterior descending artery (LAD) length and the occurrence of Takotsubo syndrome (TTS).
  • These findings suggest that structural variations in the LAD are unlikely to be primary drivers of TTS.
  • Further research into alternative pathophysiological mechanisms for TTS is warranted.
Abstract

Keywords:
Cardiovascular imagingCoronary computed tomography angiographyMyocardial bridgingTakotsubo syndrome

More Related Videos

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery08:38

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Published on: August 16, 2019

29.4K
Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy07:02

Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy

Published on: September 9, 2020

6.9K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
213
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
367
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
325
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
354