Nanofluid-Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles.
Qingsong Fan1, Junqin Chen2, Arpit Mishra2
1Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, USA.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 5, 2025
Summary
This study introduces a nanoparticle fluid to improve laser lithotripsy for urinary stones. The new method significantly enhances stone ablation efficiency with minimal tissue damage, offering a safer treatment.
Area of Science:
- Biomedical Engineering
- Materials Science
- Urology
Background:
- Urinary stone disease prevalence is increasing globally.
- Laser lithotripsy, particularly Ho:YAG laser, is a standard treatment.
- Improving laser ablation efficiency is crucial for better outcomes.
Purpose of the Study:
- To investigate a novel nanoparticle-based fluid for enhancing Ho:YAG laser lithotripsy.
- To evaluate the impact of nanofluids on stone ablation efficiency and safety.
Main Methods:
- A PEDOT:PSS nanofluid (0.03 wt.%) was used with a clinical Ho:YAG laser lithotripter.
- Ablation efficiency was measured in spot and scanning treatment modes.
- Cytotoxicity tests were performed to assess safety.
Main Results:
- Nanofluid enhanced stone ablation by 38-727% (spot) and 26-75% (scanning).
- Improved vapor tunnel formation and laser energy transmission were observed.
- No increase in thermal tissue injury and minimal cytotoxicity were confirmed.
Conclusions:
- The nanofluid approach significantly improves laser lithotripsy efficiency.
- This method shows potential for safer and more effective urinary stone treatment.
- Further research is needed for clinical translation, including aggregation and in vivo studies.
