Recent Developments in Pharmacological Outcomes of Synthetic Triazoles: A Comprehensive Review

Recent research has shown that heterocyclic compounds and their derivatives have garnered a great deal of attention in medicinal chemistry due to their noteworthy biological and pharmacological characteristics. A characteristic of both natural products and pharmaceutical drugs is the triazole nucleus which is one of the most significant heterocycles. Most pharmaceuticals include large amounts of heterocyclic nitrogen. One of the preferred structural motifs of triazoles, among nitrogen-containing heterocyclic compounds, has drawn a lot of interest from both academia and industry. Triazoles are widely used in organic synthesis, supramolecular chemistry, polymer chemistry, drug discovery, chemical biology, bioconjugation, fluorescence imaging, and materials research. Additionally, this intriguing heterocycle's many biological functions will be covered. Researchers, particularly those paying attention to the development of triazole derivatives with a number of synthetic methods-particularly the well-liked click chemistry approach-and their pharmacological outcomes such as antifungal, antitubercular, antibacterial, antiviral, and anticancer properties will find this review highly significant.