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[Large Primary Hepatic Neuroendocrine Tumor with Right Trisectionectomy-A Case Report].
Ryohei Aoyama1, Takumi Miyamoto, Kentaro Yasuchika
1Dept. of Surgery, Japanese Red Cross Wakayama Medical Center.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|October 6, 2025
Summary
A large primary hepatic neuroendocrine tumor (PHNET) was successfully resected in a 75-year-old female. Early diagnosis via advanced imaging and surgical removal led to a favorable prognosis with no recurrence after one year.
Area of Science:
- Hepatobiliary Surgery
- Oncology
- Medical Imaging
Background:
- Primary hepatic neuroendocrine tumors (PHNETs) are rare and challenging to diagnose with standard imaging.
- Early detection and accurate staging are crucial for effective treatment of liver tumors.
Purpose of the Study:
- To report a case of a large PHNET diagnosed and successfully treated with radical resection.
- To highlight the diagnostic utility of advanced imaging modalities in identifying and staging PHNETs.
Main Methods:
- Incidental detection of a large liver mass via ultrasonography.
- Characterization using CT, MRI, 18F-fluorodeoxyglucose positron emission tomography-CT (PET-CT), and somatostatin receptor scintigraphy (SRS).
- Histopathological diagnosis as neuroendocrine tumor (NET) G1, followed by surgical resection (right trisectionectomy) after portal vein embolization.
Main Results:
- A 12 cm NET G1 was diagnosed as a PHNET based on imaging and biopsy.
- No extrahepatic lesions were detected by PET-CT and SRS.
- Successful radical resection was performed with no surgical complications and no recurrence observed at 1-year follow-up.
Conclusions:
- PHNETs require advanced imaging (PET-CT, SRS) and histopathology for accurate diagnosis.
- Radical surgical resection is the primary treatment for PHNETs, offering a favorable prognosis even for large tumors.
- Multidisciplinary management, including preoperative embolization and surgical expertise, is key to successful outcomes in complex liver resections.
