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Updated: Jan 16, 2026

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
Published on: July 4, 2018
Microbiome: Friend or Friendly Foe
The human microbiome, crucial for health, can shift to a disease state (dysbiosis) due to aging and environmental factors. Maintaining its balance through diet and lifestyle is key for overall well-being.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- The human microbiome is a complex ecosystem vital for host health, including nutrition and immunity.
- Imbalances (dysbiosis) can lead to disease, influenced by aging, diet, and genetics.
Purpose of the Study:
- To review the human intestinal microbiome's role in health and disease.
- To highlight factors influencing microbiome homeostasis and strategies for its maintenance.
Main Methods:
- Literature review focusing on the human intestinal microbiome.
- Analysis of factors contributing to dysbiosis and homeostasis.
Main Results:
- Microbiome balance is essential; dysbiosis is linked to aging, weakened immunity, and inflammation.
- Factors like diet, genetics, and lifestyle significantly impact microbiome composition.
Conclusions:
- Maintaining microbiome homeostasis is achievable through dietary diversity, judicious antimicrobial use, probiotics, gut barrier support, and healthy lifestyle choices.
- These strategies are critical for preventing disease and preserving host health throughout life.
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