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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Does Vitamin D Deficiency Contribute to Growing Pains? A Case-Control Study.

Isha Jain1, Abinaya K2, Nikita Agarwal2

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Clinical Pediatrics
|October 6, 2025
PubMed
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This study found no significant difference in vitamin D levels between children with growing pains (GPs) and healthy controls. Vitamin D supplementation did not show a notable impact on pain reduction in children with GPs.

Keywords:
bone metabolismgrowing painsnon-specific childhood illnessvitamin D deficiency

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Area of Science:

  • Pediatrics
  • Nutritional Science
  • Musculoskeletal Health

Background:

  • Growing pains (GPs) are common, non-inflammatory musculoskeletal pain syndromes in children aged 4-14 years.
  • The potential link between vitamin D deficiency and the development of GPs remains an area of investigation.
  • Understanding contributing factors to GPs is crucial for effective management and parental guidance.

Purpose of the Study:

  • To investigate the association between vitamin D deficiency and the incidence of growing pains in children.
  • To evaluate the effect of vitamin D supplementation on pain reduction in children diagnosed with GPs.
  • To compare vitamin D levels and related biochemical markers between children with and without GPs.

Main Methods:

  • A 6-month case-control study involving children aged 4-14 years with and without a history of GPs.
  • Measurement of serum 25-hydroxyvitamin D (25-OHD), calcium, phosphate, and alkaline phosphatase levels.
  • Administration of vitamin D3 supplementation to participants with deficient or insufficient 25-OHD levels.

Main Results:

  • High prevalence of insufficient or deficient 25-OHD levels observed in both the GP group (95.6%) and the control group (93.3%).
  • No significant correlations were found between serum calcium, phosphate, alkaline phosphatase, and 25-OHD levels in either group.
  • Children with sufficient 25-OHD levels experienced pain reduction comparable to those receiving vitamin D supplementation.

Conclusions:

  • The study found no significant difference in vitamin D levels between children experiencing growing pains and healthy controls.
  • Vitamin D deficiency is highly prevalent in both groups, suggesting it may not be a primary causative factor for GPs.
  • Current findings do not support vitamin D supplementation as a targeted intervention for reducing growing pains in children.