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Robot-assisted partial nephrectomy using the Hugo™ RAS System: first multicentre study and Tetrafecta achievement
Francesco Prata1,2, Paolo Dell'Oglio3, Angelo Mottaran4
1Department of Urology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
BJU International
|October 6, 2025
Summary
The Hugo™ robot-assisted surgery (RAS) system demonstrates safety and effectiveness in robot-assisted partial nephrectomy (RAPN), achieving an 80% Tetrafecta rate. Surgical experience and R.E.N.A.L. score predict successful outcomes, supporting its adoption.
Area of Science:
- Urology
- Minimally Invasive Surgery
- Robotic Surgery
Background:
- Robot-assisted partial nephrectomy (RAPN) is a standard procedure for kidney tumors.
- Evaluating new robotic platforms is crucial for advancing surgical techniques.
- The Hugo™ RAS system offers a novel approach to complex urological procedures.
Purpose of the Study:
- To assess perioperative outcomes of RAPN using the Hugo™ RAS system.
- To determine the rate of Tetrafecta achievement as a measure of surgical quality.
- To identify predictors of successful Tetrafecta achievement in Hugo™ RAS RAPN cases.
Main Methods:
- Multi-center data collection from five tertiary care centers performing RAPN with the Hugo™ RAS system.
- Definition of Tetrafecta: negative margins, no major complications (Clavien-Dindo Grade ≥II), and ≤30% GFR decline at 90 days.
- Analysis of 140 RAPN cases, including operative times, blood loss, complications, and Tetrafecta achievement.
Main Results:
- Successful RAPN with the Hugo™ RAS system in 140 patients; no conversions to open surgery.
- Tetrafecta rate achieved in 80% of cases.
- R.E.N.A.L. nephrometry score and surgeon experience were independent predictors of Tetrafecta achievement (P<0.05).
Conclusions:
- The Hugo™ RAS system facilitates safe and effective RAPN.
- A high Tetrafecta rate (80%) indicates satisfactory surgical quality.
- Findings support the adoption of the Hugo™ RAS system for RAPN procedures.

