Related Experiment Video
Updated: Jan 16, 2026
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Predictors of acute adverse reactions to non-ionic iodinated contrast media in CT imaging: a systematic review and
Ke Liu1,2, Xin Cheng1, Yongli Zhu3
1Department of Nursing, North Sichuan Medical College, Nanchong, China.
Background:
Iodinated contrast media-acute adverse reactions (ICM-AARs) are frequent and clinically significant complications associated with radiological imaging. Despite investigation of their risk factors, there is no consensus, and no comprehensive synthesis has been conducted. This systematic review and meta-analysis aimed to investigate the factors influencing ICM-AARs.
Methods:
A systematic search for studies published in Chinese or English up to 22 July 2024 in the PubMed, Web of Science, Cochrane Library, Embase, CNKI, WanFang, CQVIP, and SinoMed databases was conducted. Studies on patients undergolng contrast-enhanced CT examinations with nonionic ICM were selected. The primary outcome measures were risk factors associated with ICM-AARs. The studies were analyzed for heterogeneity using the Q-test and I2 statistic, while publication bias was assessed using funnel plots, Egger's test, and Begg's test. Stata 17 software was used for the meta-analysis.
Results:
Seventeen studies were included, encompassing 2,576,446 CT-enhanced examinations. Of these, 11,621 acute adverse reactions were reported, with a mean incidence of 0.45% and a quality score of ≥7. The meta-analysis showed that female sex (OR = 1.27, 95% CI = 1.13, 1.41), age <35 years (OR = 1.77, 95% CI = 1.19, 2.64), high body mass index (OR = 1.06, 95% CI = 1.01, 1.10), type of medical visit (outpatient) (OR = 2.23, 95% CI = 1.01, 4.93), history of adverse ICM reactions (OR = 11.03, 95% CI = 2.25, 53.97), history of other allergies (OR = 3.16, 95% CI = 1.27, 7.84), history of asthma (OR = 1.75, 95% CI = 1.19, 2.57), hyperthyroldism (OR = 4.59, 95% CI = 1.65, 12.82), and type of ICM (OR = 2.27, 95% CI = 1.68, 3.06) were risk factors for ICM-AARs. Age >60 years (OR = 0.71, 95% CI = 0.53, 0.95), pre-injection medication (OR = 0.56, 95% CI = 0.39, 0.79), and hypertensive disorders (OR = 0.78, 95% CI = 0.65, 0.94) were identified as protective against ICM-AARs.
Conclusions:
The incidence of ICM-AARs is influenced by a variety of clinical and demographic factors. Healthcare professionals may benefit from dynamically assessing patient-specific risk factors and considering targeted preventive measures for high-risk groups, particularly in populations similar to those studied.
Systematic Review Registration:
https://www.crd.york.ac.uk/PROSPERO/, PROSPERO (CRD42024571470).
More Related Videos
06:02Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
Published on: April 18, 2013
08:13In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Related Concept Videos
01:30Radiological Investigation I: X-ray and CT
01:27Imaging Studies III: Computed Tomography
01:28Imaging Studies for Cardiovascular System V: CT
01:14Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
01:21Imaging Studies for Cardiovascular System IV: CMRI
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT