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Multimaterial bioprinting and combination of processing techniques towards the fabrication of biomimetic tissues and organs.

Biofabrication·2021

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Tough PEGDA-Based Bioadhesive Hydrogels for High-Strength In Situ Cartilage Adhesion.

Kerem Veral¹, Rumeysa Tutar¹

¹Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpaşa, Avcılar, Istanbul 34320, Turkey.

|October 6, 2025

Summary

This study developed a novel injectable hydrogel from polyethylene glycol diacrylate (PEGDA) and methacrylated alginate (AlgMA) to enhance cartilage repair. The new bioadhesive demonstrates superior strength and adhesion for effective cartilage tissue sealing.

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Area of Science:

Biomaterials Science
Tissue Engineering
Musculoskeletal Medicine

Background:

Articular cartilage injuries pose significant challenges in musculoskeletal medicine due to limited natural regeneration.
Current treatments often fall short in providing robust and durable repair for cartilage defects.

Purpose of the Study:

To formulate and evaluate novel injectable, in situ double-cross-linkable bioadhesive hydrogels for improved cartilage repair.
To enhance both the adhesive and cohesive properties of hydrogels for superior cartilage tissue sealing.

Main Methods:

Synthesized polyethylene glycol diacrylate (PEGDA) and methacrylated alginate (AlgMA) hydrogels.
Investigated the interaction between the hydrogel framework and cartilage tissue amine thiols to form amide bonds and thioesters.
Assessed hydrogel properties including physical/chemical characteristics, swelling, degradation, burst pressure, lap shear, and wound closure strength in vitro and ex vivo.

Main Results:

The developed PEGDA/AlgMA hydrogels exhibited significantly high ex vivo burst pressure (up to 194.5 ± 8.5 kPa) and lap shear strength (335.5 ± 3.5 kPa).
In vitro and ex vivo wound closure strengths reached 643.5 ± 46 kPa and 138 ± 8.5 kPa, respectively, outperforming clinical fibrin adhesives.
The hydrogels demonstrated robust adhesion and cohesion, crucial for effective tissue sealing.

Conclusions:

The composite hydrogel technology represents a superior bioactive adhesive for cartilage tissue sealing and repair.
These findings support the advancement of nature-inspired biomaterials for clinical applications in regenerative medicine.
The developed hydrogel holds promise for next-generation bioadhesives in treating cartilage injuries.