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Epigenetic regulation espeically histone modifications in breast cancer: A viable and emerging targeted therapeutic

Yibing Zhou1, Haotian Liu2, Weimin Hong3

  • 1Central Laboratory, Department of Scientific Research, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, 215500, Jiangsu Province, China.

Journal of Cancer
|October 6, 2025
PubMed

Insights

Epigenetic regulation, particularly histone modifications, influences breast cancer progression and treatment response. Targeting these epigenetic factors offers promising new therapeutic strategies for breast cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Epigenetic regulation modifies gene expression without altering DNA sequences.
  • Dysregulated epigenetic mechanisms, including histone modifications, are implicated in breast cancer initiation and progression.
  • Histone modifications are vital for genomic stability, DNA repair, and chromatin dynamics in breast cancer.

Purpose of the Study:

  • To review current research on epigenetic regulatory factors in breast cancer.
  • To focus on the role of histone modifications in breast cancer treatment.
  • To explore the impact of epigenetic modifications on radiotherapy and chemotherapy efficacy.

Main Methods:

  • Literature review of epigenetic regulatory factors in breast cancer.
  • Analysis of histone modifications in breast cancer treatment.
  • Examination of the interplay between epigenetic modifications and cancer therapies.

Main Results:

  • Histone modifications significantly influence breast cancer initiation, progression, and treatment outcomes.
  • Epigenetic alterations can suppress or enhance the expression of genes driving breast cancer.
  • The effectiveness of radiotherapy and chemotherapy is modulated by epigenetic changes.

Conclusions:

  • Epigenetic regulatory factors, especially histone modifications, are critical in breast cancer.
  • Understanding these mechanisms can improve current breast cancer treatments.
  • Epigenetic targets hold significant potential for developing novel breast cancer therapies.
Keywords:
DNA methylation inhibitorsbreast cancerepigenetic regulationhistone modificationhistone target inhibitors

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