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Updated: Jan 16, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Zn(OAc)2·2H2O‑Catalyzed Sulfurization Reaction of Alkenes: A Selective and Direct One-Pot Synthesis of
Patamawadee Silalai1, Suwichada Jaipea1, Rungnapha Saeeng1,2
1Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand.
Abstract:
β-Hydroxysulfides are valuable intermediates in pharmaceutical and synthetic chemistry. In this study, we present an efficient method for synthesizing β-hydroxysulfides via the radical pathway for sulfurization reaction of alkenes using Zn-(OAc)2·2H2O as an inexpensive and environmentally friendly catalyst, yielding products in good to excellent yields. Notably, vinylpyridine serves as an effective substrate, leading to the formation of unique thioetherpyridine products in high yields. These products are versatile and can undergo additional transformations, broadening their synthetic utility. The advantages of this method include a broad substrate scope, mild conditions, and high compatibility with various functional groups.
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Analogous to alkenes, alkynes also undergo acid-catalyzed hydration. While the addition of water to an alkene gives an alcohol, hydration of alkynes produces different products such as aldehydes and ketones.
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