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Bloomy Rind Sign in Leptomeningeal Metastasis of Primary Lung Adenocarcinoma
Wenyuan Tao1, Xinhua Chen2, Xin Zhang3
1Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China.
Clinical Case Reports
|October 6, 2025
Abstract:
The bloomy rind sign, which appears as hyperintensities on FLAIR along the surface of the brainstem without gadolinium contrast enhancement, is a rare and early finding indicative of leptomeningeal metastasis in patients with lung adenocarcinoma, often associated with EGFR gene mutations.

