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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation

Anna Kirstein1, Dan Ionascu2, Michael A S Lamba2

  • 1Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Clinical and Translational Radiation Oncology
|October 6, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Head and Neck Squamous Cell Carcinoma (HNSCC)Proton therapyRadiationRelative biological effectiveness (RBE)X-ray radiation

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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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