Associations Between the Triglyceride-Glucose Index Along with Its Combinations with Obesity Indicators and Kidney...

Relationships of triglyceride-glucose (TyG) index and TyG combined with obesity indicators [TyG-waist circumference (TyG-WC), TyG-waist height ratio (TyG-WHtR), TyG-body mass index (TyG-BMI)] with kidney stone (KS) have been infrequently investigated among the American. This study aimed to examine these relationships within a substantial, nationwide population.

The current cross-sectional study recruited totally 9,808 adult participants in National Health and Nutrition Examination Survey (NHANES) 2007-2018. For investigating relations of the TyG index, TyG-WC, TyG-WHtR, and TyG-BMI with KS, multivariate logistic regression, restricted cubic spline (RCS), mediation, sensitivity, subgroup and interaction analyses were used.

This analysis indicated that TyG combined with obesity indicators [TyG-WC, (odds ratio (OR) = 2.19, 95% CI: 1.69-2.84, P < 0.001); TyG-WHtR, (OR = 2.26, 95% CI: 1.73-2.95, P < 0.001); TyG-BMI, (OR = 1.88, 95% CI: 1.48-2.39, P < 0.001)] exhibited a stronger correlation with KS compared to the TyG index alone (OR = 1.40, 95% CI: 1.10-1.78, P = 0.006). Based on RCS analysis, TyG index and TyG combined with obesity indicators were linearly related to KS (P-overall < 0.0001, P-nonlinear > 0.05). Mediation analysis indicated that high-density lipoprotein cholesterol (HDL-C) had a significant mediating effect.

In this study, TyG index and TyG combined with obesity indicators (TyG-WC, TyG-WHtR and TyG-BMI) show a significantly positive relationship to KS. Furthermore, in comparison to the TyG index alone, TyG combined with obesity indicators exhibited enhanced diagnostic relevance.