Modern Endophthalmitis Control: The Complete Early Vitrectomy for Endophthalmitis (CEVE) Protocol and Surgical...

Area of Science:

• Ophthalmology
• Infectious Diseases
• Surgical Innovation

Background:

• Endophthalmitis is a severe intraocular inflammation following surgery, injections, or trauma, with potential for vision loss.
• Diverse pathogens (bacteria, fungi, viruses) can cause endophthalmitis, especially in immunocompromised individuals.
• Rapid intervention is critical to prevent vision-threatening complications and systemic sepsis.

Purpose of the Study:

• To review the practical application of the Complete Early Vitrectomy for Endophthalmitis (CEVE) protocol in outpatient settings.
• To discuss preventive strategies for endophthalmitis, focusing on antimicrobial use.
• To evaluate the role of prophylactic antibiotics in intraocular procedures and intravitreal injections.

Main Methods:

• Review of the Complete Early Vitrectomy for Endophthalmitis (CEVE) protocol.
• Analysis of preventive strategies for ocular surgery and injections.
• Evaluation of antimicrobial use and resistance patterns.

Main Results:

• The CEVE protocol demonstrates broad efficacy across various endophthalmitis causes.
• Povidone-iodine (PI) is highly effective for perioperative antisepsis.
• Prophylactic antibiotics are recommended for brief topical use post-intraocular procedures; routine use after intravitreal injections is not supported.

Conclusions:

• The CEVE approach offers a robust treatment strategy for endophthalmitis.
• Optimizing antimicrobial stewardship is crucial to combat resistance.
• Evidence-based guidelines for prophylactic antibiotic use are essential for intraocular procedures and injections.