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Acute Hypersensitivity Reaction With Maculopapular Exanthem and Angio-Oedema Following Low Dose Amitriptyline for

Bhanu Priya Singh1, Anna Javed2, Sartaj Hussain2

  • 1Pharmacology, Shri Mata Vaishno Devi Institute of Medical Excellence, Katra, IND.

Cureus
|October 6, 2025
PubMed

We report a case of a 34‑year‑old woman who developed a generalized maculopapular rash accompanied by urticaria‑like pruritus, angio‑oedema, and mild dyspnoea. The reaction occurred approximately one hour after ingestion of her routine 10 mg dose of amitriptyline, following four weeks of therapy for migraine prophylaxis. Laboratory studies showed elevated erythrocyte sedimentation rate (ESR) and CRP with normal eosinophil counts and negative viral serology; imaging was unremarkable. Causality, assessed with the World Health Organization-Uppsala Monitoring Centre system (WHO‑UMC) and Naranjo algorithms, was "probable." Prompt cessation of the medication, H1 receptor antagonism combined with leukotriene‑receptor blockade, and supportive treatment resulted in complete recovery by day eight, with no recurrence observed at the three-month follow-up. This case expands the limited literature on tricyclic antidepressant (TCA)-induced hypersensitivity and emphasizes the importance of timely recognition, discontinuation, and pharmacovigilance reporting for patient safety.

Keywords:
adverse drug reactionamitriptylinedrug hypersensitivitymaculopapular exanthemtricyclic antidepressants

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