Cardiac Rehabilitation in Patients with Coronary Heart Disease-Challenges, Inequalities, and Opportunities for Global

Vagner Madrini1,2, Monica T A Albuquerque1, Caio A M Tavares1,2

  • 1Hospital Israelita Albert Einstein, São Paulo, Brazil.

Global Heart
|October 6, 2025
PubMed

Insights

Cardiac rehabilitation (CR) is underutilized globally despite strong evidence for secondary prevention in heart disease. Improving access and implementation is crucial for patient outcomes and health equity.

Area of Science:

  • Cardiology
  • Public Health
  • Health Services Research

Background:

  • Cardiac rehabilitation (CR) is a Class I recommended secondary prevention strategy for coronary heart disease.
  • Despite proven benefits in reducing morbidity, mortality, and improving quality of life, CR is significantly underutilized globally.
  • The INTERASPIRE study revealed a substantial gap between CR evidence and its implementation, marked by low referral and adherence rates.

Purpose of the Study:

  • To highlight the global underutilization of cardiac rehabilitation (CR).
  • To identify barriers and inequities in CR referral and adherence.
  • To underscore the need for improved CR implementation and access.

Main Methods:

  • Analysis of global CR referral and adherence data, as exemplified by the INTERASPIRE study.
  • Examination of systemic factors contributing to the evidence-implementation gap.
  • Review of existing literature on CR benefits and barriers.

Main Results:

  • Cardiac rehabilitation (CR) programs are strikingly underutilized worldwide, despite robust evidence supporting their efficacy.
  • Significant inequities in CR access and utilization persist across different regions and socioeconomic groups.
  • Systemic failures in translating guideline recommendations into practice were identified as key drivers of low CR implementation.

Conclusions:

  • Addressing the global underutilization of CR requires significant investment in infrastructure and equitable referral strategies.
  • Standardization of CR program content and exploration of innovative delivery models like telehealth are essential.
  • Ensuring universal access to CR is a critical clinical imperative and a matter of health equity for cardiovascular disease patients.

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