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Updated: Jan 15, 2026

Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Tetraimidazolium macrocycle: a versatile building block and precursor for box-type coordination cages
1School of Chemistry and Chemical Engineering, Yan'an University Yan'an 716000 P. R. China wangf@yau.edu.cn.
Abstract:
This study describes a facile synthesis of the imidazolium-based cyclophane H4-1(PF6)4 from 1-(1H-imidazol-1-ylmethyl)-1H-imidazole and 1,4-bis(bromomethyl)benzene, followed by anion exchange. Slipped π-π stacking interactions between the flexible cyclophane and aromatic sulfonate anions-including the 1,5-naphthalenedisulfonate dianion (1,5-nds), 2,6-naphthalenedisulfonate dianion (2,6-nds), and 2,7-naphthalenedisulfonate dianion (2,7-nds)-induce one-dimensional (1D) self-assembly, forming nanochannels. Significantly, a metallocage, Ag4(1)2(PF6)4 is derived from the corresponding tetraimidazolium salt via reaction with Ag2O and subsequent transmetalation. This cyclophane-based metallocage possesses an optimal size for binding acetonitrile and exhibits excellent selectivity for acetonitrile encapsulation, mediated by weak N⋯Ag interactions.
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