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Histone acetyltransferase 1 promotes ovarian cancer progression by regulating cell proliferation and the cell cycle

Xiao Han1, Ling Liu1, Jing Li1

  • 1Department of Medical Genetic and Prenatal Diagnosis, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

Oncology Letters
|October 6, 2025
PubMed

Insights

Histone acetyltransferase 1 (HAT1) is upregulated in ovarian cancer (OC), promoting cell growth. Inhibiting HAT1 suppressed OC cell proliferation and may offer a new therapeutic target for ovarian cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Ovarian cancer (OC) is a leading cause of gynecological cancer mortality.
  • Histone acetyltransferase 1 (HAT1) is implicated in various diseases, including cancer, but its role in OC is unexplored.

Purpose of the Study:

  • To investigate the role of HAT1 in ovarian cancer.
  • To determine the prognostic significance of HAT1 expression in OC.
  • To explore the regulatory mechanisms and functional impact of HAT1 in OC cells.

Main Methods:

  • Analysis of HAT1 expression in OC tissues.
  • Correlation of HAT1 expression with patient prognosis.
  • Investigation of the transcriptional regulation of HAT1 by forkhead box protein A1 (FOXA1).
  • Assessment of HAT1 knockdown effects on OC cell proliferation, colony formation, and cell cycle progression.
  • Measurement of cell cycle-related proteins, including cyclin-dependent kinase (CDK)2, CDK4, and cyclin E.

Main Results:

  • HAT1 was found to be upregulated in OC.
  • High HAT1 expression correlated with unfavorable prognosis in OC patients.
  • FOXA1 was identified as a transcriptional regulator of HAT1.
  • HAT1 knockdown significantly inhibited OC cell proliferation and colony formation.
  • HAT1 inhibition induced cell cycle arrest and decreased levels of CDK2, CDK4, and cyclin E.

Conclusions:

  • HAT1 plays an oncogenic role in ovarian cancer.
  • HAT1 expression is regulated by FOXA1.
  • HAT1 represents a potential novel therapeutic target for ovarian cancer treatment.
Keywords:
cell cycleforkhead box protein A1histone acetyltransferase 1ovarian cancertumor growth

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