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Asthma in Pregnancy
Eve Denton1,2, Megan E Jensen3, Bronwyn K Brew3
1Asthma, Allergy and Clinical Immunology, The Alfred Hospital, Melbourne, Victoria, Australia.
Allergy
|October 6, 2025
Summary
Asthma affects pregnant women, with respiratory changes impacting its severity unpredictably. Uncontrolled asthma increases risks for mothers and babies, highlighting the need for safe treatment options during pregnancy.
Area of Science:
- Obstetrics and Gynecology
- Pulmonology
- Clinical Immunology
Background:
- Asthma is a prevalent chronic respiratory condition in pregnant individuals.
- Pregnancy induces significant physiological respiratory changes, affecting asthma control variably.
- Uncontrolled asthma during pregnancy is linked to adverse maternal and fetal outcomes.
Purpose of the Study:
- To review current evidence on asthma epidemiology in pregnancy.
- To discuss pregnancy-related respiratory alterations and their impact on asthma.
- To explore comorbidities and treatment strategies for asthma during gestation.
Main Methods:
- Literature review of epidemiological data.
- Analysis of physiological changes in the respiratory system during pregnancy.
- Examination of comorbidity prevalence and impact.
- Assessment of current and emerging asthma treatment options.
Main Results:
- Asthma prevalence varies globally in pregnant populations.
- Respiratory system modifications during pregnancy can unpredictably alter asthma status.
- Medication non-adherence due to safety concerns is a key factor in asthma control loss.
- Metabolic comorbidities are increasingly recognized as significant factors in asthma and pregnancy outcomes.
- Observational data suggest potential safety for biologics like omalizumab and dupilumab, though further research is required.
Conclusions:
- Effective asthma management during pregnancy is crucial for optimizing maternal and fetal health.
- Addressing medication adherence and comorbidities is essential for maintaining asthma control.
- Further research is needed to confirm the safety and efficacy of specific asthma therapies in pregnant women.
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